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Factores genéticos en la nefropatía por IgA

En él se comparan 930 pacientes con 768 controles y no se ha encontrado relación entre los polimorfismos de la uteroglobina y el desarrollo o progresión de la IgAN (20).

Conclusiones

En los últimos años se han producido grandes avances en la determinación de los factores genéticos que influyen en el desarrollo de nefropatía por IgA. No obstante, no todos los pacientes con IgA primaria responden a alguna de los genotipos aquí descritos ni todos los individuos con alguno de estos genes desarrollan la enfermedad. Son necesarios más estudios para poder alcanzar conclusiones más precisas.

Bibliografía

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  2. Scolari F. et al : Familial clustering of IgA nephropathy: further evidence in an Italian population. American Journal of Kidney Disease 33: 857-865; 1999.
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  7. Luigi  Bisceglia, Giuseppina  Cerullo, Paola  Forabosco, Diletta Domenica  Torres, Francesco  Scolari, Michele  Di Perna, Marina  Foramitti, Antonio  Amoroso, Sara  Bertok, Jürgen  Floege, Peter Rene  Mertens, Klaus  Zerres, Efstathios  Alexopoulos, Dimitrios  Kirmizis, Mazzucco  Ermelinda, Leopoldo  Zelante, Francesco Paolo  Schena. Genetic Heterogeneity in Italian Families with IgA Nephropathy: Suggestive Linkage for Two Novel IgA Nephropathy Loci. Am J Hum Genet. 2006 December; 79(6): 1130–1134.
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  13. Tuglular S, Berthoux P, Berthoux F: Polymorphisms of the tumour necrosis factor alpha gene at position –308 and TNFd microsatellite in primary IgA nephropathy. Nephrol Dial Transplant 2003; 18: 724–731.
  14. Masutani K, Miyake K, Nakashima H, Hirano T, Kubo M, Hirakawa M, et al: Impact of interferon- gamma and interleukin-4 gene polymorphisms on development and progression of IgA nephropathy in Japanese patients. Am J Kidney Dis 2003; 41: 371–379.
  15. Li YJ, Du Y, Li CX, Guo H, Leung JC, Lam MF, et al: Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3 _ untranslated region of the Megsin gene. J Am Soc Nephrol 2004; 15: 1739–1743.
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  19. Zheng F, Kundu GC, Zhang Z, et al. Uteroglobin is essential in preventing immunoglobin A nephropathy in mice. Nat Med 1999;5:1018.Yong D, QingQing W, Hua L, et al. Association of uteroglobin G38A polimorphism with IgA nephropathy: a meta-analysis. Am J Kidney Dis 2006; 48:1.
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