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El asma necesita nuevas drogas

entidad. Los ICSs son muy eficaces, pero solo suprimen síntomas que normalmente retornan al suspender el tratamiento. Las perspectivas para una cura parecen remotas, y causas moleculares y genéticas aun no están totalmente aclaradas. Es posible que un objetivo importante en el proceso inflamatorio podría ser la terapia anti-TNF como la usada en artritis reumatoide, pero estos objetivos sólo son identificables en modelos de laboratorio. Las metas más selectivas en los pacientes con sub fenotipos particulares (endotipos) de asma puede ser posible en el futuro gracias al desarrollo de biomarcadores y del perfil genético

Ha sido comprobado lo difícil que es encontrar nuevas terapias para el control del asma bronquial, a pesar del intenso esfuerzo e inversión. El asma es una enfermedad muy compleja, por lo que es improbable que el control de un solo receptor o mediador sería muy eficaz. Los corticosteroides son eficaces porque suprimen múltiples mecanismos inflamatorios en paralelo. Los otros tratamientos necesitan desarrollar una vía oral eficaz para los pacientes con la enfermedad ligera y moderada, pero esto ha demostrado ser un desafío mayor, porque es probable que cualquier terapia eficaz tenga peligrosos efectos colaterales y seria menos útil que los medicamentos actualmente en uso.

Referencias bibliográficas

Barnes J P. New Drugs for Asthma. Semin Respir Crit Care Med. 2012;33(6):685-94

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